反应详情

温度

25 °C

A 4.0 M solution of HCl in 1,4-dioxane (10 ml) was added to a solution of 4-[1-benzenesulfonyl-5-(2-cyclopentyl-acetylamino)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.222 g, 0.382 mmol) in 1,4-dioxane (10 ml) at 25° C. The reaction mixture was stirred at 25° C. for 1 h, then was concentrated under reduced pressure to afford crude N-[1-benzenesulfonyl-4-(piperidin-4-ylamino)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-cyclopentyl-acetamide (hydrochloride salt) as a white solid. This material was used in the next step below without additional purification or characterization.

1. concentrationwas concentrated under reduced pressure