反应详情

A solution of racemic cis 3-methoxycarbonylamino-4-methyl-piperidine-1-carboxylic acid tert-butyl ester (2.00 g, 7.35 mmol) in 4 M HCl in dioxane (40 mL) was stirred at ambient temperature for 1 hour then concentrated under vacuum. The resulting residue was azeotroped with DCM to afford 1.7 g (quant.) of racemic cis (4-methyl-piperidin-3-yl)-carbamic acid methyl ester hydrochloride. LCMS (Method I, ESI): RT=0.34 min, m+H=173.4.

1. concentrationthen concentrated under vacuum
2. customThe resulting residue was azeotroped with DCM