(3-Cyano-cyclohexyl)-carbamic acid tert-butyl ester → 3-Aminocyclohexanecarbonitrile

HRID 1257717Notes

Reaction equation

HRID 1257717 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]#[N:15])[CH2:9]1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]#[N:15])[CH2:9]1

Participants

3

Reactant 1

HCID 67323270(3-Cyano-cyclohexyl)-carbamic acid tert-butyl ester

Product 1

HCID 215121773-Aminocyclohexanecarbonitrile

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

(3-Cyano-cyclohexyl)-carbamic acid tert-butyl ester (0.74 g, 3.30 mmol) was dissolved in TFA/DCM and stirred for 1 hr. The solvent was evaporated to give 3-amino-cyclohexanecarbonitrile as a brown solid. The crude material was used without further purification. LCMS (Method H, ESI): RT=0.35 min, m+H=125.0.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-6c81fa16458e4082ad5c0f26caae71e6
Source dataset
uspto-grants-2013_06
Patent number
US08461328B2

Reaction notes

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