HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Cyano-cyclohexyl)-carbamic acid tert-butyl ester → 3-Aminocyclohexanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Cyano-cyclohexyl)-carbamic acid tert-butyl ester | HCID 67323270 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | 3-Aminocyclohexanecarbonitrile | HCID 21512177 | — |
Reaction Steps
(3-Cyano-cyclohexyl)-carbamic acid tert-butyl ester (0.74 g, 3.30 mmol) was dissolved in TFA/DCM and stirred for 1 hr. The solvent was evaporated to give 3-amino-cyclohexanecarbonitrile as a brown solid. The crude material was used without further purification. LCMS (Method H, ESI): RT=0.35 min, m+H=125.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461328B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-6c81fa16458e4082ad5c0f26caae71e6 |
| Source note | uspto-grants-2013_06 |