HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1257774Generated: November 3, 2026
1-Pentanol → 6-(4-Fluorophenyl)-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine
https://huagongshe.com/reaction/1257774
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Pentanol | HCID 6276 | — |
| Reactant | 2-Chloro-3-(4-methoxyphenyl)propanal | HCID 12102756 | — |
| Reactant | 5-(4-Fluorophenyl)pyrimidin-2-amine | HCID 12946647 | — |
| Product | 6-(4-Fluorophenyl)-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine | HCID 25145512 | — |
Reaction Steps
A mixture of 5-(4-fluorophenyl)pyrimidin-2-amine (50 mg, 0.3 mmol), 2-chloro-3-(4-methoxyphenyl)propanal (52 mg, 0.26 mmol) in tent-amyl alcohol (1.0 mL) in a sealed reaction vial was heated at 130° C. for 3 hours. After cooling, the mixture was purified by preparative HPLC to afford the desired product. LCMS: (M+H)=334.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08461330B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-ff35776f4c2e478d972db69801e4c66b |
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| Source note | uspto-grants-2013_06 |
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