Hydrochloric Acid → Hydrochloric Acid

HRID 1257820Notes

Reaction equation

HRID 1257820 reaction equation
C([O:5][C:6](=[O:35])[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:14]=[N:15][C:16]3[N:17]([C:19]([C:22]4([C:25]5[CH:26]=[C:27]6[C:32](=[CH:33][CH:34]=5)[N:31]=[CH:30][CH:29]=[CH:28]6)[CH2:24][CH2:23]4)=[CH:20][N:21]=3)[CH:18]=2)=[CH:9][CH:8]=1)(C)(C)C.[ClH:36]>O1CCOCC1>[N:31]1[C:32]2[C:27](=[CH:26][C:25]([C:22]3([C:19]4[N:17]5[CH:18]=[C:13]([C:10]6[CH:11]=[CH:12][C:7]([C:6]([OH:35])=[O:5])=[CH:8][CH:9]=6)[CH:14]=[N:15][C:16]5=[N:21][CH:20]=4)[CH2:23][CH2:24]3)=[CH:34][CH:33]=2)[CH:28]=[CH:29][CH:30]=1.[ClH:36]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67223697Tert-butyl 4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzoate

Product 2

HCID 313Hydrochloric AcidYield 99.5%HCID 672233304-[3-(1-Quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzoic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzoate (0.125 g, 0.27 mmol) was treated with 4M HCl in 1,4-dioxane (1.5 mL) at RT for 3 h. The mixture was decanted. The solid was washed with ether and dried to give the desired product as HCl salt (129 mg, 99.5%) which was directly used in next step without further purification. LCMS: (M+H)=407.1.

Workup

  1. customThe mixture was decanted
  2. washThe solid was washed with ether
  3. customdried

Sources & evidence

ORD record
ord-c80fc5070b8d4c938a3fc190f4bfc42a
Source dataset
uspto-grants-2013_06
Patent number
US08461330B2

Reaction notes

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