HRID1257839

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67223366

未命名化合物

HCID86621504

未命名化合物

PRODUCTS

生成物

结构：O=C(COc1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)cc1)N1CCCC1

HCID25144818

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度: 90 °C

PROCEDURE

实验过程

A mixture of 5-[4-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]pyrimidin-2-amine (23.9 mg, 0.08 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (19.6 mg, 0.08 mmol) in isopropyl alcohol (0.4 mL) was heated at 90° C. overnight. The mixture was diluted with methanol, and purified by RP-HPLC (pH 10) to give the desired product. LCMS: (M+H)=490.1.

WORKUP

后处理

custompurified by RP-HPLC (pH 10)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f06e9250fda2425e92a507125ac90454
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08461330B2
来源说明: uspto-grants-2013_06

反应 SMILES

[O:1]=[C:2]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[N:13][C:14]([NH2:17])=[N:15][CH:16]=2)=[CH:7][CH:6]=1.Cl[CH:24]([C:27]1([C:30]2[CH:31]=[C:32]3[C:37](=[CH:38][CH:39]=2)[N:36]=[CH:35][CH:34]=[CH:33]3)[CH2:29][CH2:28]1)[CH:25]=O>C(O)(C)C.CO>[O:1]=[C:2]([N:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1)[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[N:13][C:14]3[N:15]([C:24]([C:27]4([C:30]5[CH:31]=[C:32]6[C:37](=[CH:38][CH:39]=5)[N:36]=[CH:35][CH:34]=[CH:33]6)[CH2:29][CH2:28]4)=[CH:25][N:17]=3)[CH:16]=2)=[CH:7][CH:6]=1