HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1257839Generated: October 26, 2026
5-[4-(2-Oxo-2-pyrrolidin-1-ylethoxy)phenyl]pyrimidin-2-amine → 6-(1-{6-[4-(2-Oxo-2-pyrrolidin-1-ylethoxy)phenyl]imidazo[1,2-a]pyrimidin-3-yl}cyclopropyl)quinoline
https://huagongshe.com/reaction/1257839
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-[4-(2-Oxo-2-pyrrolidin-1-ylethoxy)phenyl]pyrimidin-2-amine | HCID 67223366 | — |
| Reactant | Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde | HCID 86621504 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-(1-{6-[4-(2-Oxo-2-pyrrolidin-1-ylethoxy)phenyl]imidazo[1,2-a]pyrimidin-3-yl}cyclopropyl)quinoline | HCID 25144818 | — |
Reaction Steps
A mixture of 5-[4-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]pyrimidin-2-amine (23.9 mg, 0.08 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (19.6 mg, 0.08 mmol) in isopropyl alcohol (0.4 mL) was heated at 90° C. overnight. The mixture was diluted with methanol, and purified by RP-HPLC (pH 10) to give the desired product. LCMS: (M+H)=490.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08461330B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-f06e9250fda2425e92a507125ac90454 |
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| Source note | uspto-grants-2013_06 |
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