Trifluoroacetic acid → 6-(1-{6-[1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]imidazo[1,2-a]pyrimidin-3-yl}cyclopropyl)quinoline

HRID 1257862Notes

Reaction equation

HRID 1257862 reaction equation
C(O)(C(F)(F)F)=O.[O:8]1[CH2:12][CH2:11][CH:10]([N:13]2[CH:17]=[C:16]([C:18]3[CH:19]=[N:20][C:21]([NH2:24])=[N:22][CH:23]=3)[CH:15]=[N:14]2)[CH2:9]1.Cl[CH:26]([C:29]1([C:32]2[CH:33]=[C:34]3[C:39](=[CH:40][CH:41]=2)[N:38]=[CH:37][CH:36]=[CH:35]3)[CH2:31][CH2:30]1)[CH:27]=O>>[O:8]1[CH2:12][CH2:11][CH:10]([N:13]2[CH:17]=[C:16]([C:18]3[CH:23]=[N:22][C:21]4[N:20]([C:26]([C:29]5([C:32]6[CH:33]=[C:34]7[C:39](=[CH:40][CH:41]=6)[N:38]=[CH:37][CH:36]=[CH:35]7)[CH2:31][CH2:30]5)=[CH:27][N:24]=4)[CH:19]=3)[CH:15]=[N:14]2)[CH2:9]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 672240915-[1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amineHCID 86621504Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde

Product 1

HCID 251455176-(1-{6-[1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]imidazo[1,2-a]pyrimidin-3-yl}cyclopropyl)quinoline

Procedure

The title compound was prepared as a TFA salt from the condensation of 5-[1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde using a procedure analogous to that described for the synthesis of Example 7, Step 8. LCMS: (M+H)=423.1.

Workup

  1. customthat described for the synthesis of Example 7, Step 8

Sources & evidence

ORD record
ord-071b86d40210402d986128aa4f943bb6
Source dataset
uspto-grants-2013_06
Patent number
US08461330B2

Reaction notes

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