γ-Methylene-6-quinolinepropanol → HCID 67223946, compound

HRID 1257886Notes

Reaction equation

HRID 1257886 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](=[CH2:15])[CH2:12][CH2:13][OH:14])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1>[Pt].CO>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH:11]([CH3:15])[CH2:12][CH2:13][OH:14])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 67224309γ-Methylene-6-quinolinepropanol

Product 1

HCID 67223946HCID 67223946, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 3-quinolin-6-ylbut-3-en-1-ol (1.0 g, 0.0050 mol), platinum on carbon (5 wt. % supported on activated carbon, wet, Degussa type F101 ra/w, 0.20 g) in methanol (15.0 mL) was stirred under hydrogen (with a balloon) at RT for 5 h. The mixture was filtered and the filtrate was concentrated to give the desired product (1.0 g, 99%). LCMS: (M+H)=202.1.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-022e37fc89e0400d8e5167cfaae56324
Source dataset
uspto-grants-2013_06
Patent number
US08461330B2

Reaction notes

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