Methylphenidate Hydrochloride → Methylphenidate

HRID 1257957Notes

Reaction equation

HRID 1257957 reaction equation
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl>O>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Participants

3

Reactant 1

HCID 9280Methylphenidate Hydrochloride

Product 1

HCID 4158Methylphenidate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methylphenidate hydrochloride (392 g) and Avicel® PH101 (208 g) were loaded in a GPCG-1 fluidized bed processor equipped with a rotor. Then, spherical particles were prepared by spraying water (500 g) while operating the rotor at 1400 rpm. When spherical particles with a size of 150 to 300 μm were prepared, the spraying was stopped and the particles were dried at 50° C. for 10 minutes. After stopping the rotation, the product was dried in a convection oven for 8 hours, and then sieved. Particles with a size of 150-300 μm (438 g) were obtained. The drug content measured by HPLC was about 64.9%.

Workup

  1. customequipped with a rotor
  2. customThen, spherical particles were prepared
  3. customWhen spherical particles with a size of 150 to 300 μm were prepared
  4. customthe particles were dried at 50° C. for 10 minutes
  5. customthe product was dried in a convection oven for 8 hours
  6. filtrationsieved
  7. customParticles with a size of 150-300 μm (438 g) were obtained

Sources & evidence

ORD record
ord-80eb0fb42d6042cf856c38c5d3439ae0
Source dataset
uspto-grants-2013_06
Patent number
US08465768B2

Reaction notes

Loading…