Methylphenidate Hydrochloride → Methylphenidate

Participants

Reaction Steps

Methylphenidate hydrochloride (392 g) and Avicel® PH101 (208 g) were loaded in a GPCG-1 fluidized bed processor equipped with a rotor. Then, spherical particles were prepared by spraying water (500 g) while operating the rotor at 1400 rpm. When spherical particles with a size of 150 to 300 μm were prepared, the spraying was stopped and the particles were dried at 50° C. for 10 minutes. After stopping the rotation, the product was dried in a convection oven for 8 hours, and then sieved. Particles with a size of 150-300 μm (438 g) were obtained. The drug content measured by HPLC was about 64.9%.

Provenance & Evidence