Morpholine → HCID 59338811, compound

HRID 12580Notes

Reaction equation

HRID 12580 reaction equation
Cl[C:2]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)=[CH:6][C:3]=1[C:4]#[N:5].[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>CN(C=O)C>[O:26]1[CH2:27][CH2:28][N:23]([C:2]2[N:9]=[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:7]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)=[CH:6][C:3]=2[C:4]#[N:5])[CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 59338823HCID 59338823, compound2×

Product 1

HCID 59338811HCID 59338811, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-chloro-6-phenyl-5-p-tolylnicotinonitrile (Compound 115, 124 mg, 0.4 mmol) and morpholine (36 mg, 0.4 mmol) in DMF (2 ml) was heated at 150° C. for 2 hours. The solvents was removed and the residue was purified by MPLC column chromatography (silica gel, 10% ethyl acetate in hexane) to obtain the title compound as a white solid.

Workup

  1. customThe solvents was removed
  2. customthe residue was purified by MPLC column chromatography (silica gel, 10% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-e4e6c63a3c704d84b663b5daf5e4cb4e
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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