HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Potassium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | ethyl 1H-pyrazole-4-carboxylate | HCID 142179 | — |
| Reactant | ethyl 1-{[3-(trifluoromethyl)phenyl]methyl}-1H-pyrazole-4-carboxylate | HCID 21916388 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Potassium Hydroxide | HCID 14797 | — |
| Product | 1-(3-(Trifluoromethyl)benzyl)-1H-pyrazole-4-carboxylic acid | HCID 11492741 | — |
Reaction Steps
Ethyl pyrazole-4-carboxylate is reacted with 1-(bromomethyl)-3-(trifluoromethyl)benzene in acetone in the presence of potassium carbonate. The product, ethyl 1-{[3-(trifluoromethyl)phenyl]methyl}pyrazole-4-carboxylate, is then hydrolyzed with potassium hydroxide in methanol, to provide 1-{[3-(trifluoromethyl)phenyl]methyl}pyrazole-4-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466129B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-96f7d17ab329407cb3ca8c69d95e0b21 |
| Source note | uspto-grants-2013_06 |