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HRID1258019

反应详情

EQUATION

反应方程式

HRID 1258019 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：FC(F)(F)c1cccc(CBr)c1
HCID123061

1-(Bromomethyl)-3-(trifluoromethyl)benzene

C8H6BrF3

结构：CCOC(=O)c1cn[nH]c1
HCID142179

4-Acetylpyrazole

C6H8N2O2

结构：CCOC(=O)c1cnn(Cc2cccc(C(F)(F)F)c2)c1
HCID21916388

未命名化合物

PRODUCTS

生成物

2
结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：O=C(O)c1cnn(Cc2cccc(C(F)(F)F)c2)c1
HCID11492741

1-{[3-(Trifluoromethyl)phenyl]methyl}-1H-pyrazole-4-carboxylic acid

C12H9F3N2O2

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Ethyl pyrazole-4-carboxylate is reacted with 1-(bromomethyl)-3-(trifluoromethyl)benzene in acetone in the presence of potassium carbonate. The product, ethyl 1-{[3-(trifluoromethyl)phenyl]methyl}pyrazole-4-carboxylate, is then hydrolyzed with potassium hydroxide in methanol, to provide 1-{[3-(trifluoromethyl)phenyl]methyl}pyrazole-4-carboxylic acid.