3,4-Difluorobenzoyl chloride → HCID 11428459, compound

HRID 1258042Notes

Reaction equation

HRID 1258042 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:12]2[S:13][CH:14]=[CH:15][C:11]=2[CH2:10][CH2:9][NH:8][CH:7]=1)=[O:5])[CH3:2].[F:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[F:26])[C:20](Cl)=[O:21]>>[CH2:1]([O:3][C:4]([C:6]1[C:12]2[S:13][CH:14]=[CH:15][C:11]=2[CH2:10][CH2:9][N:8]([C:20](=[O:21])[C:19]2[CH:23]=[CH:24][C:25]([F:26])=[C:17]([F:16])[CH:18]=2)[CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27245193,4-Difluorobenzoyl chlorideHCID 69434939HCID 69434939, compound

Product 1

HCID 11428459HCID 11428459, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2 by using 5,6-dihydro-4H-thieno[2,3-d]azepine-8-carboxylic acid ethyl ester and 3,4-difluoro-benzoyl chloride. 1H-NMR(CDCl3): δ 8.01 (1 H, s), 7.47 (1 H, m), 7.36 (1H, m), 7.27 (2H, m), 6.85 (1H, d), 4.23 (2H, q), 4.13 (2H, m), 3.15 (2H, t), 1.23 (3H, t). MS (ES): 364 (MH+).

Sources & evidence

ORD record
ord-fed000342443435a8a8ed76f6bdc2e91
Source dataset
uspto-grants-2013_06
Patent number
US08466143B2

Reaction notes

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