反应详情

(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-indan-1-ylamine (1.60 g) is dissolved in 16 mL DCM and combined with triethylamine (2.54 mL). Then methanesulphonyl chloride (0.61 mL in 5 mL DCM) is added dropwise. The reaction mixture is stirred for 2 h and after elimination of the solvent it is purified by normal phase chromatography (cHex/EA). The product-containing fractions are combined and freed from the solvent using the rotary evaporator.

1. customafter elimination of the solvent it is purified by normal phase chromatography (cHex/EA)
2. customthe rotary evaporator