p-Toluenesulfonic acid → HCID 59354801, compound

HRID 1258333Notes

Reaction equation

HRID 1258333 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:8]([C:11](=[O:22])[C:12]#[C:13][C:14]([CH3:21])([O:16][Si](C)(C)C)[CH3:15])=[CH:7][C:4]=1[C:5]#[N:6].CC1C=CC(S(O)(=O)=O)=CC=1>C(Cl)Cl.O>[OH:16][C:14]([CH3:21])([CH3:15])[C:13]#[C:12][C:11]([C:8]1[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[C:4]([CH:7]=1)[C:5]#[N:6])=[O:22]

Participants

5

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 593548212-Methoxy-5-(4-methyl-4-(trimethylsilyloxy)pent-2-ynoyl)benzonitrile

Product 1

HCID 59354801HCID 59354801, compoundYield 122.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 2-methoxy-5-(4-methyl-4-(trimethylsilyloxy)pent-2-ynoyl)benzonitrile (1.2 g, 3.01 mmol) in DCM (20 mL) was added PTSA (1.08 g, 5.60 mmol) at RT. The reaction mixture was stirred for 30 minutes and diluted with water (5 mL). The combined organic layers were then washed with a saturated NaHCO3 solution and water, dried over Na2SO4, filtered, and then concentrated in vacuo to afford 5-(4-hydroxy-4-methylpent-2-ynoyl)-2-methoxybenzonitrile (0.9 g, 97%) as a semi-solid.

Workup

  1. washThe combined organic layers were then washed with a saturated NaHCO3 solution and water
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-01a7f5a5d90e4a8aabcc0073ee4e084b
Source dataset
uspto-grants-2013_06
Patent number
US08466148B2

Reaction notes

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