HCID 44608987, compound → HCID 44608990, compound

HRID 1258382Notes

Reaction equation

HRID 1258382 reaction equation
C([O:5][C:6](=[O:29])[CH2:7][O:8][C:9]1[CH:18]=[C:17]([NH:19][S:20]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)(=[O:22])=[O:21])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]=1[OH:28])(C)(C)C>O1CCOCC1.Cl>[OH:28][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([NH:19][S:20]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)(=[O:22])=[O:21])=[CH:18][C:9]=1[O:8][CH2:7][C:6]([OH:29])=[O:5]

Participants

4

Reactant 1

HCID 44608987HCID 44608987, compound

Product 1

HCID 44608990HCID 44608990, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl-2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-yloxy)acetate (9d, 0.025 g, 0.057 mmol) was dissolved in 4 ml of 1:1 ratio of dioxane and concentrated hydrochloric acid and stirred at r.t. for 3 h. The mixture solution changed from clear to white cloudy. The solvent was evaporated under reduced pressure. The solid was washed with DCM and hexane separately to get pure product as a gray solid, 97%, m.p.=155-157° C.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washThe solid was washed with DCM and hexane separately
  3. customto get pure product as a gray solid, 97%, m.p.=155-157° C.

Sources & evidence

ORD record
ord-f319577fce7a48a1b8a96112c3c7f6f1
Source dataset
uspto-grants-2013_06
Patent number
US08466157B2

Reaction notes

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