反应详情

81.6 mg 12b was dissolved in 2 ml THF. 1 ml THF solution containing 1 eq. 1-methyl-tetrazole-5-thiol and 1 eq. pyridine was added. The mixture was shaken for 30 min. The organic solvent was removed by V-10 (biotage). The residue was suspended in 10 ml water and sonicated thoroughly. The insoluble was filtered and washed with water. The solid was dried over air affording 96.5 mg (99.0%) title compound 13x.

1. customThe organic solvent was removed by V-10 (biotage)
2. customsonicated thoroughly
3. filtrationThe insoluble was filtered
4. washwashed with water
5. customThe solid was dried over air