Hydrochloric Acid → HCID 67220219, compound

HRID 1258460Notes

Reaction equation

HRID 1258460 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:9]2[C:10]3[O:11][CH:12]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:13][CH2:14][C:15]=3[C:16]([C:18]([O:20]C)=[O:19])=[CH:17][C:8]=2[N:7]=[C:6]1[CH3:28].[OH-].[Na+].Cl>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:9]2[C:10]3[O:11][CH:12]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:13][CH2:14][C:15]=3[C:16]([C:18]([OH:20])=[O:19])=[CH:17][C:8]=2[N:7]=[C:6]1[CH3:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67220457HCID 67220457, compound

Product 1

HCID 67220219HCID 67220219, compoundYield 96.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of methyl 1-(2-methoxyethyl)-2-methyl-8-phenyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylate (1.37 g, 3.61 mmol, Step 11), 2 mol/L sodium hydroxide aqueous solution (3.60 mL, 7.21 mmol), and ethanol (20 mL) was stirred at 80° C. for 2 hours. After cooling to room temperature, 2 mol/L hydrochloric acid (3.60 mL, 7.21 mmol) was added, and the formed precipitate was collected by filtration to afford the title compound as a white solid (1.28 g, 96%).

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe formed precipitate was collected by filtration

Sources & evidence

ORD record
ord-18f39a08a079469b9cee34f429e24b29
Source dataset
uspto-grants-2013_06
Patent number
US08466166B2

Reaction notes

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