2-(Methylamino)ethanol → 7-(Benzyloxy)-N-(2-hydroxyethyl)-1-(2-methoxyethyl)-N,2-dimethyl-1H-benzimidazole-5-carboxamide

HRID 1258474Notes

Reaction equation

HRID 1258474 reaction equation
[CH2:1]([O:8][C:9]1[C:14]2[N:15]([CH2:19][CH2:20][O:21][CH3:22])[C:16]([CH3:18])=[N:17][C:13]=2[CH:12]=[C:11]([C:23]([OH:25])=O)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][NH:27][CH2:28][CH2:29][OH:30]>>[CH2:1]([O:8][C:9]1[C:14]2[N:15]([CH2:19][CH2:20][O:21][CH3:22])[C:16]([CH3:18])=[N:17][C:13]=2[CH:12]=[C:11]([C:23]([N:27]([CH2:28][CH2:29][OH:30])[CH3:26])=[O:25])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 672204647-(Benzyloxy)-1-(2-methoxyethyl)-2-methyl-1H-benzimidazole-5-carboxylic acid

Product 1

HCID 672195387-(Benzyloxy)-N-(2-hydroxyethyl)-1-(2-methoxyethyl)-N,2-dimethyl-1H-benzimidazole-5-carboxamideYield 99%

Procedure

The title compound was prepared as a white amorphous in 99% yield from 7-(benzyloxy)-1-(2-methoxyethyl)-2-methyl-1H-benzimidazole-5-carboxylic acid (5.00 g, 14.7 mmol, Step 5 of Example 1) and 2-(methylamino)ethanol (1.21 g, 16.2 mmol) by the same manner in Step 13 of Example 1.

Sources & evidence

ORD record
ord-6ed2874392044637937958215cad5b56
Source dataset
uspto-grants-2013_06
Patent number
US08466166B2

Reaction notes

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