HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → 7-(Benzyloxy)-N-(2-hydroxyethyl)-1-(2-methoxyethyl)-N,2-dimethyl-1H-benzimidazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | 7-(Benzyloxy)-1-(2-methoxyethyl)-2-methyl-1H-benzimidazole-5-carboxylic acid | HCID 67220464 | — |
| Product | 7-(Benzyloxy)-N-(2-hydroxyethyl)-1-(2-methoxyethyl)-N,2-dimethyl-1H-benzimidazole-5-carboxamide | HCID 67219538 | 99% |
Reaction Steps
The title compound was prepared as a white amorphous in 99% yield from 7-(benzyloxy)-1-(2-methoxyethyl)-2-methyl-1H-benzimidazole-5-carboxylic acid (5.00 g, 14.7 mmol, Step 5 of Example 1) and 2-(methylamino)ethanol (1.21 g, 16.2 mmol) by the same manner in Step 13 of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466166B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-6ed2874392044637937958215cad5b56 |
| Source note | uspto-grants-2013_06 |