反应详情

温度

200 °C

To a solution of 6-methylpyridine-2-carbaldehyde (3.7 g, 30.54 mmol, 1 eq.) in 10 ml of ethylene glycol was added TsOH.H2O (6.67 g, 32.07 mmol, 1.05 eq.). The reaction was heated in microwave at 200° C. for 180 s (fixed hold absorb high). The mixture was added to a stirred solution of 10 g of K2CO3 in 200 ml of water, and was extracted with DCM (3×150 ml). The combined organics were washed with water evaporated on RFE (water bath 25° C.) to give 2-(1,3-dioxolan-2-yl)-6-methylpyridine (3.7 g, 51% yield) as pale brown liquid.

1. custom(fixed hold absorb high)
2. additionThe mixture was added to a stirred solution of 10 g of K2CO3 in 200 ml of water
3. extractionwas extracted with DCM (3×150 ml)
4. washThe combined organics were washed with water
5. customevaporated on RFE (water bath 25° C.)