反应详情

温度

90 °C

Sat. aq. NH4Cl (50 mL) followed by iron powder (5.51 g, 98.7 mmol) were added at rt to a mixture of tert-butyl 4-chloro-3-nitrobenzylcarbamate (5.66 g, 19.7 mmol) and EtOH (50 mL). After stirring for 4 h at 80° C., 4 h at 90° C. and at rt overnight the reaction mixture was filtered through celite and washed with EtOAc. The aq. layer was extracted with EtOAc. The combined extracts were washed with brine, dried over Na2SO4 and concentrated to give the sub-title compound.

1. filtrationwas filtered through celite
2. washwashed with EtOAc
3. extractionThe aq. layer was extracted with EtOAc
4. washThe combined extracts were washed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated