1,1'-Thiocarbonyldi-2(1H)-pyridone → HCID 86646343, compound

HRID 1258634Notes

Reaction equation

HRID 1258634 reaction equation
[C:1](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:2].[NH2:17][C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][C:31]=1[Cl:32])[CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25]>C(Cl)Cl>[Cl:32][C:31]1[CH:30]=[CH:29][C:20]([CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])=[CH:19][C:18]=1[N:17]=[C:1]=[S:2]

Participants

4

Reactant 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 66765386N-(3-amino-4-chlorobenzyl)pivalamide

Product 1

HCID 86646343HCID 86646343, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1′-Thiocarbonyldi-2-pyridone (2.12 g, 9.1 mmol) was added to a mixture of N-(3-amino-4-chlorobenzyl)-2,2-dimethyl-propionamide (2.00 g, 8.3 mmol) and DCM (60 mL) and stirred at rt for 1.5 h. The mixture was filtered over silica gel. The organic layer was concentrated to give the sub-title compound.

Workup

  1. filtrationThe mixture was filtered over silica gel
  2. concentrationThe organic layer was concentrated

Sources & evidence

ORD record
ord-7125d667e7ff480ebce03b54f597e544
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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