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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258640Generated: October 30, 2026

Hydrochloric Acid → HCID 178483274, compound

https://huagongshe.com/reaction/1258640

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 178483275HCID 178483275—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178483274HCID 178483274—

Reaction Conditions

Temperature50 °C

Reaction Steps

6 M aq. HCl-solution (1.0 ml) was added to N-{4-chloro-3-[5-chloro-6-(3-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-carbamic acid tert-butyl ester (130 mg, 0.2 mmol) in THF (2 mL) and stirred at 50° C. for 1 h. The reaction mixture was concentrated to give the sub-title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08466186B2
Source datasetuspto-grants-2013_06
ORD IDord-4957761839a24456b2af356d5d0e04b9
Source noteuspto-grants-2013_06