HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258640Generated: October 30, 2026
Hydrochloric Acid → HCID 178483274, compound
https://huagongshe.com/reaction/1258640
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178483275 | HCID 178483275 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178483274 | HCID 178483274 | — |
Reaction Steps
6 M aq. HCl-solution (1.0 ml) was added to N-{4-chloro-3-[5-chloro-6-(3-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-carbamic acid tert-butyl ester (130 mg, 0.2 mmol) in THF (2 mL) and stirred at 50° C. for 1 h. The reaction mixture was concentrated to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08466186B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-4957761839a24456b2af356d5d0e04b9 |
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| Source note | uspto-grants-2013_06 |
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