Hydrochloric Acid → HCID 178483274, compound

HRID 1258640Notes

Reaction equation

HRID 1258640 reaction equation
Cl.C(OC(=O)[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([NH:17][C:18]2[NH:22][C:21]3[CH:23]=[C:24]([N:28]4[CH2:32][CH2:31][CH:30]([CH2:33][N:34]([CH3:36])[CH3:35])[CH2:29]4)[C:25]([Cl:27])=[CH:26][C:20]=3[N:19]=2)[CH:11]=1)(C)(C)C>C1COCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][NH2:8])=[CH:11][C:12]=1[NH:17][C:18]1[NH:22][C:21]2[CH:23]=[C:24]([N:28]3[CH2:32][CH2:31][CH:30]([CH2:33][N:34]([CH3:36])[CH3:35])[CH2:29]3)[C:25]([Cl:27])=[CH:26][C:20]=2[N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178483275HCID 178483275, compound

Product 1

HCID 178483274HCID 178483274, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

6 M aq. HCl-solution (1.0 ml) was added to N-{4-chloro-3-[5-chloro-6-(3-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-carbamic acid tert-butyl ester (130 mg, 0.2 mmol) in THF (2 mL) and stirred at 50° C. for 1 h. The reaction mixture was concentrated to give the sub-title compound.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-4957761839a24456b2af356d5d0e04b9
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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