N-(4-Chloro-3-nitrobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide → N-(3-amino-4-chlorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	N-(4-Chloro-3-nitrobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide	HCID 59529820	—
Catalyst	Nickel	HCID 935	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	N-(3-amino-4-chlorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide	HCID 59529866	—

Reaction Steps

A mixture of N-(4-chloro-3-nitro-benzyl)-1-trifluoromethyl-cyclopropanecarboxamide (340 mg, 1.1 mmol), EtOAc (10 mL) and Ra—Ni (30 mg) was stirred at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the filtrate was concentrated to give the sub-title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08466186B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-302a24cf37774c0e89455b41ef8cce08
Source note	uspto-grants-2013_06