HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Chloro-2-methylamino-4-(4-methyl-piperazin-1-yl)-aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4-Chloro-5-(4-methyl-piperazin-1-yl)-2-nitro-N-methyl-aniline | HCID 44120649 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Chloro-2-methylamino-4-(4-methyl-piperazin-1-yl)-aniline | HCID 67957923 | — |
Reaction Steps
The sub-title compound was prepared from 4-chloro-5-(4-methyl-piperazin-1-yl)-2-nitro-N-methyl-aniline (500 mg, 1.8 mmol), THF (6 mL), MeOH (6 mL) and Pt/C (50 mg) in analogy to example 1 step (f).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-409c9c8301cb43649345f2976b99f5b7 |
| Source note | uspto-grants-2013_06 |