Tetrahydrofuran → 5-Chloro-2-methylamino-4-(4-methyl-piperazin-1-yl)-aniline

HRID 1258672Notes

Reaction equation

HRID 1258672 reaction equation
[Cl:1][C:2]1[C:9]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:17]([O-])=O)[CH:3]=1.C1COCC1>[Pt].CO>[Cl:1][C:2]1[C:9]([N:10]2[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([CH:3]=1)[NH2:17]

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 441206494-Chloro-5-(4-methyl-piperazin-1-yl)-2-nitro-N-methyl-aniline

Product 1

HCID 679579235-Chloro-2-methylamino-4-(4-methyl-piperazin-1-yl)-aniline

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

The sub-title compound was prepared from 4-chloro-5-(4-methyl-piperazin-1-yl)-2-nitro-N-methyl-aniline (500 mg, 1.8 mmol), THF (6 mL), MeOH (6 mL) and Pt/C (50 mg) in analogy to example 1 step (f).

Sources & evidence

ORD record
ord-409c9c8301cb43649345f2976b99f5b7
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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