N-methyl-2-nitro-4-(4-trifluoromethyl-piperidin-1-yl)-aniline → HCID 67957856, compound

HRID 1258675Notes

Reaction equation

HRID 1258675 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[CH:5][C:4]=1[N+:19]([O-])=O>[Pd].CO>[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:10][CH2:11][CH:12]([C:15]([F:18])([F:16])[F:17])[CH2:13][CH2:14]2)=[CH:5][C:4]=1[NH2:19]

Participants

4

Reactant 1

HCID 67958090N-methyl-2-nitro-4-(4-trifluoromethyl-piperidin-1-yl)-aniline

Product 1

HCID 67957856HCID 67957856, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of N-methyl-2-nitro-4-(4-trifluoromethyl-piperidin-1-yl)-aniline (220 mg, 0.7 mmol), MeOH (7 mL) and Pd/C (30 mg) was stirred for 18 h at rt under a hydrogen atmosphere (3.0 bar). The catalyst was removed by filtration, the filtrate was concentrated and directly used in the next step.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-59bd1007a75e4742a198fd0c4fca9248
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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