HCID 67957856, compound → HCID 86674333, compound

HRID 1258676Notes

Reaction equation

HRID 1258676 reaction equation
[CH3:1][NH:2][C:3]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]2)=[CH:6][C:4]=1[NH2:5].[Cl:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][NH:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:23][C:22]=1[N:35]=[C:36]=[S:37]>C1COCC1>[Cl:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][NH:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:23][C:22]=1[NH:35][C:36]([NH:5][C:4]1[CH:6]=[C:7]([N:10]2[CH2:11][CH2:12][CH:13]([C:16]([F:19])([F:17])[F:18])[CH2:14][CH2:15]2)[CH:8]=[CH:9][C:3]=1[NH:2][CH3:1])=[S:37]

Participants

4

Reactant 2

HCID 67957856HCID 67957856, compoundHCID 86646343HCID 86646343, compound

Product 1

HCID 86674333HCID 86674333, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2-methylamino-5-(4-trifluoromethyl-piperidin-1-yl)aniline (90 mg, 0.3 mmol) and N-(4-chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide (93 mg, 0.3 mmol) in THF (10 mL) was stirred at rt for 4 h. The reaction mixture was concentrated and directly used in the next step. Yield: 180 mg (98%). HPLC-method A: Rt=2.23 min. MS m/z: 556 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-43b63221dd1c42a6b9b53d74b617dbdf
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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