反应详情

DIC (130 μL, 0.8 mmol) was added to N-(4-chloro-3-{3-[2-methylamino-5-(4-trifluoromethyl-piperidin-1-yl)-phenyl]-thioureido}-benzyl)-2,2-dimethyl-propionamide (180 mg, 0.3 mmol) in MeCN. The reaction mixture was heated at 60° C.-80° C. for one week (additional DIC (2.5 ml) was added). The mixture was cooled to rt and concentrated. The residue was treated with MeCN, filtered and washed. The filtercake was diluted with dioxane and HCOOH and lyophilized to give the title compound.

1. temperatureThe reaction mixture was heated at 60° C.-80° C. for one week
2. concentrationconcentrated
3. additionThe residue was treated with MeCN
4. filtrationfiltered
5. washwashed
6. additionThe filtercake was diluted with dioxane and HCOOH