Potassium Carbonate → HCID 44120656, compound

HRID 1258690Notes

Reaction equation

HRID 1258690 reaction equation
[Cl:1][C:2]1[C:8](Cl)=[CH:7][C:5]([NH2:6])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.Cl.[F:14][C:15]([F:23])([F:22])[CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[Cl:1][C:2]1[C:8]([N:19]2[CH2:20][CH2:21][CH:16]([C:15]([F:23])([F:22])[F:14])[CH2:17][CH2:18]2)=[CH:7][C:5]([NH2:6])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 811494,5-Dichloro-2-nitroanilineHCID 162181604-(Trifluoromethyl)piperidine hydrochloride

Product 1

HCID 44120656HCID 44120656, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The sub-title compound was prepared from 4,5-dichloro-2-nitro-aniline (500 mg, 2.4 mmol), 4-trifluoromethyl-piperidine hydrochloride (550 mg, 2.9 mmol) and K2CO3 (830 mg, 6.0 mmol) in DMSO (10 mL) in analogy to example 3, step (a).

Sources & evidence

ORD record
ord-3ee7a657b0ed4220a221ed77ef862f74
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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