HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Amino-2,4-difluoro-benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,4-Difluoro-3-nitrobenzonitrile | HCID 45790497 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-2,4-difluoro-benzylamine | HCID 56839969 | — |
Reaction Steps
A mixture of 3-Nitro-2,4-difluoro-benzonitrile (0.50 g, 2.7 mmol), MeOH (25 ml), 37% HCl (1.5 ml) and Pd/C (200 mg) was stirred for 13 h at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the filtrate was concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-f6575bf7168b45d4b5567619c4764a90 |
| Source note | uspto-grants-2013_06 |