Hydrochloric Acid → 3-Amino-2,4-difluoro-benzylamine

HRID 1258694Notes

Reaction equation

HRID 1258694 reaction equation
[N+:1]([C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[C:7]#[N:8])([O-])=O.Cl>[Pd].CO>[NH2:1][C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[CH2:7][NH2:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 457904972,4-Difluoro-3-nitrobenzonitrile

Product 1

HCID 568399693-Amino-2,4-difluoro-benzylamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 3-Nitro-2,4-difluoro-benzonitrile (0.50 g, 2.7 mmol), MeOH (25 ml), 37% HCl (1.5 ml) and Pd/C (200 mg) was stirred for 13 h at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the filtrate was concentrated.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f6575bf7168b45d4b5567619c4764a90
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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