HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258701Generated: November 1, 2026
Potassium Carbonate → 4-(Methylamino)-5-nitro-2-(4-trifluoromethyl-piperidin-1-yl)benzonitrile
https://huagongshe.com/reaction/1258701
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4-(Trifluoromethyl)piperidine | HCID 136469 | — |
| Reactant | 2-Chloro-4-(methylamino)-5-nitrobenzonitrile | HCID 67957627 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(Methylamino)-5-nitro-2-(4-trifluoromethyl-piperidin-1-yl)benzonitrile | HCID 67957822 | — |
Reaction Steps
A mixture of 2-chloro-4-(methylamino)-5-nitrobenzonitrile (3.07 g, 14.5 mmol), 4-trifluoromethylpiperidine (3.33 g, 21.7 mmol), K2CO3 (5.01 g, 36.2 mmol) and DMF (16 mL) was heated at 60° C. for 6 h under Ar atmosphere. The mixture was poured into aqueous NH4OH and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated. Crystallization from EtOAc/PE gave the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08466186B2 |
|---|
| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-b49684c80e684482b844da77f2e73f83 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
