反应详情

温度

60 °C

A mixture of 2-chloro-4-(methylamino)-5-nitrobenzonitrile (3.07 g, 14.5 mmol), 4-trifluoromethylpiperidine (3.33 g, 21.7 mmol), K2CO3 (5.01 g, 36.2 mmol) and DMF (16 mL) was heated at 60° C. for 6 h under Ar atmosphere. The mixture was poured into aqueous NH4OH and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated. Crystallization from EtOAc/PE gave the sub-title compound.

1. extractionextracted with EtOAc
2. dry with materialThe organic layer was dried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. customCrystallization from EtOAc/PE