HRID1258718

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12734

Diisopropylcarbodiimide

C7H14N2

HCID67958171

未命名化合物

HCID86646335

未命名化合物

PRODUCTS

生成物

结构：Cn1c(Nc2cc(CNC(=O)OC(C)(C)C)ccc2Cl)nc2cc(Cl)c(N3CCC(C(F)(F)F)CC3)cc21

HCID67975169

未命名化合物

PROCEDURE

实验过程

The sub-title compound was prepared in analogy to Example 76 using 5-chloro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline (508 mg, 1.65 mmol), tert-butyl 4-chloro-3-isothiocyanatobenzylcarbamate (493 mg, 1.65 mmol), DIC (208 mg, 1.65 mmol) and

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd6d57e9386549b8be71f4b604e3f93a
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08466186B2
来源说明: uspto-grants-2013_06

反应 SMILES

[Cl:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][CH:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]2)=[CH:4][C:5]([NH:9][CH3:10])=[C:6]([CH:8]=1)[NH2:7].[Cl:21][C:22]1[CH:36]=[CH:35][C:25]([CH2:26][NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:24][C:23]=1[N:37]=[C:38]=S.CC(C)N=C=NC(C)C>>[Cl:21][C:22]1[CH:36]=[CH:35][C:25]([CH2:26][NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:24][C:23]=1[NH:37][C:38]1[N:9]([CH3:10])[C:5]2[CH:4]=[C:3]([N:11]3[CH2:16][CH2:15][CH:14]([C:17]([F:19])([F:20])[F:18])[CH2:13][CH2:12]3)[C:2]([Cl:1])=[CH:8][C:6]=2[N:7]=1