反应详情

A mixture of 3-(5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino)-4-trifluoromethyl-benzonitrile (1.20 g; 2.39 mmol), Ra—Ni (14 mg; 0.24 mmol) and THF (50 mL) was shaken under H2-atmosphere (5 atm) overnight at rt. The mixture was filtered through celite and the celite pad was washed with THF and EtOAc. Concentration and crystallization from Et2O/PE gave the sub-title compound.

1. filtrationThe mixture was filtered through celite
2. washthe celite pad was washed with THF and EtOAc
3. concentrationConcentration and crystallization from Et2O/PE