3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → Methyl 3-amino-3-(3-ethoxy-4-methoxyphenyl)propanoate

HRID 1258788Notes

Reaction equation

HRID 1258788 reaction equation
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH2:32][CH3:33])[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH2:32][CH3:33])[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

Participants

3

Reactant 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 41021513-Amino-3-(3-ethoxy-4-methoxyphenyl)propanoic acid

Product 1

HCID 21250975Methyl 3-amino-3-(3-ethoxy-4-methoxyphenyl)propanoate

Procedure

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)propionic acid was substituted with 3-amino-3-(3-ethoxy-4-methoxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 6.77-6.86 (m, 3H), 4.30 (s, 1H), 3.85 (t, 2H, J=5 Hz), 3.79 (s, 3H), 3.62 (s, 3H), 2.59 (s, 2H), 1.85 (d, 2H, J=5 Hz), 1.40 (s, 3H).

Sources & evidence

ORD record
ord-739d7b03f9b7458dbe3aeaebe0834f25
Source dataset
uspto-grants-2013_06
Patent number
US08466191B2

Reaction notes

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