3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → Methyl 3-amino-3-(3-methoxy-4-propoxy-phenyl)propionate

HRID 1258792Notes

Reaction equation

HRID 1258792 reaction equation
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

Participants

3

Reactant 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 35631203-Amino-3-(3-methoxy-4-propoxyphenyl)propanoic acid

Product 1

HCID 2946246Methyl 3-amino-3-(3-methoxy-4-propoxy-phenyl)propionate

Procedure

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)propionic acid was substituted with 3-amino-3-(3-methoxy-4-propoxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 6.77-6.86 (m, 3H), 4.32 (q, 1H, J=5 Hz), 3.87-3.95 (m, 2H), 3.80 (s, 3H), 3.61 (s, 3H), 2.62 (d, 2H, J=5 Hz), 1.76 (s, 2H), 0.97 (t, 3H, J=6 Hz).

Sources & evidence

ORD record
ord-b8bc3914c6964e55a09f48f381e819ed
Source dataset
uspto-grants-2013_06
Patent number
US08466191B2

Reaction notes

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