3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → Methyl 3-amino-3-(3-methoxy-4-benzyloxy-phenyl)propionate

HRID 1258795Notes

Reaction equation

HRID 1258795 reaction equation
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[C:25]([O:37][CH3:38])[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[C:25]([O:37][CH3:38])[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

Participants

3

Reactant 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 52302833-Amino-3-[4-(benzyloxy)-3-methoxyphenyl]propanoic acid

Product 1

HCID 68471182Methyl 3-amino-3-(3-methoxy-4-benzyloxy-phenyl)propionate

Procedure

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)propionic acid was substituted with 3-amino-3-(3-methoxy-4-benzyloxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 7.26-7.44 (m, 5H), 6.75-6.94 (m, 3H), 5.13 (s, 2H), 4.35 (t, 1H, J=5 Hz), 3.89 (s, 3H), 3.61 (s, 3H), 2.59 (d, 2H, J=5 Hz), 1.84 (d, 2H, J=5 Hz)

Sources & evidence

ORD record
ord-e8c7ea99a62c4ef7b872aae6281e701f
Source dataset
uspto-grants-2013_06
Patent number
US08466191B2

Reaction notes

Loading…