3-Amino-3-methyloxetane → HCID 57377476, compound

HRID 1258920Notes

Reaction equation

HRID 1258920 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][N:19]=4)[CH:17]=3)=[C:11]([CH3:27])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:28][C:29]1([NH2:33])[CH2:32][O:31][CH2:30]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:26]=[CH:25][C:21]([C:22]([NH:33][C:29]5([CH3:28])[CH2:32][O:31][CH2:30]5)=[O:23])=[CH:20][N:19]=4)[CH:17]=3)=[C:11]([CH3:27])[N:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 67956048HCID 67956048, compound

Product 1

HCID 57377476HCID 57377476, compoundYield 86%

Procedure

As described for example 36b, 6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (56 mg, 0.154 mmol) was converted, using 3-methyloxetan-3-amine instead of isopropylamine, to the title compound (57 mg, 86%) which was obtained as an off white solid. MS: m/e=434.3 [M+H]+.

Sources & evidence

ORD record
ord-367f1bc9c30b4a69bfcfcf40e302df70
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

Loading…