反应详情

温度

50 °C

NaOH (1 M deoxygenated aqueous solution, 100 mL) was dropwise added to DL-N-acetylhomocysteine thiolactone (4.00 g, 25.124 mmol). Addition time: 15 min. The reaction mixture was warmed up to 50° C. and allowed to react for 30 min. The reaction was cooled down to 0° C., acidified with HCl (10% aqueous solution, 30 mL) and the product was extracted with nBuOH (4×70 mL). The organic layer was dried over Na2SO4 (anhydrous), filtered and concentrated. The crude residue was slurred with Et2O/hexanes (1:3, 150 mL) to furnish 4.00 g of DL-N-acetylhomocysteine (white solid, yield: 90%).

1. additionAddition time
2. custom15 min
3. customto react for 30 min
4. temperatureThe reaction was cooled down to 0° C.
5. extractionthe product was extracted with nBuOH (4×70 mL)
6. dry with materialThe organic layer was dried over Na2SO4 (anhydrous)
7. filtrationfiltered
8. concentrationconcentrated