Pyrazole → 1-(4-chlorophenyl)-1H-pyrazole

HRID 1259319Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[CH:12][CH:11]=[N:10]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 1048Pyrazole

HCID 7806p-Bromochlorobenzene

Product 1

HCID 122381321-(4-chlorophenyl)-1H-pyrazole

Procedure

1-(4-Chlorophenyl)-1H-pyrazole was prepared from 1-bromo-4-chlorobenzene and pyrazole according to the procedure of Cristau et al., Eur. J. Org. Chem. 2004, 4, 695-709.

Sources & evidence

ORD record: ord-49e5eec0450d474297f2fa2c2f9c2d53
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08466284B2

Reaction notes

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