HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67193085, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 67191802 | HCID 67191802 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67193085 | HCID 67193085 | 51% |
Reaction Steps
Following the procedure set forth in Example 1 for the preparation of I-1g, 1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (280 mg, 0.001 mol) in THF (30 mL) was reacted with zinc (211 mg, 0.003 mol) and HCl (1 mL) to afford 250 mg of the crude product which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466289B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-2361260a845c43948065904c96018fc0 |
| Source note | uspto-grants-2013_06 |