Hydrochloric Acid → HCID 67193085, compound

HRID 1259366Notes

Reaction equation

HRID 1259366 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([N+:28]([O-])=O)[C:14]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:21]=3[F:27])=[C:15]([CH3:18])[C:16](=[O:17])[N:11]2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C1COCC1.[Zn]>[NH2:28][C:13]1[C:14]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:21]=2[F:27])=[C:15]([CH3:18])[C:16](=[O:17])[N:11]2[CH2:10][CH2:9][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:12]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67191802HCID 67191802, compound

Product 1

HCID 67193085HCID 67193085, compoundYield 51%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure set forth in Example 1 for the preparation of I-1g, 1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (280 mg, 0.001 mol) in THF (30 mL) was reacted with zinc (211 mg, 0.003 mol) and HCl (1 mL) to afford 250 mg of the crude product which was used in the next step without further purification.

Sources & evidence

ORD record
ord-2361260a845c43948065904c96018fc0
Source dataset
uspto-grants-2013_06
Patent number
US08466289B2

Reaction notes

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