反应详情

Osmium tetra oxide (8 mg, 0.035 mmol), 2,6-lutidine (0.08 g, 0.74 mmol) and sodium periodate (0.3 g, 0.001 mol) were added to a solution of 1-allyl-cyclopropanesulfonic acid [7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-a]pyridin-8-yl]-amide (0.19 g, 0.35 mmol) in dioxane (7 mL) and water (2 mL). The resulting mixture was stirred at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in DCM). The reaction mixture was partitioned between ethylacetate and water. The organic layer was washed with water, brine solution, dried over Na2SO4, filtered and the filtrate was concentrated. Purification by column chromatography on silica gel (2% MeOH in DCM) afforded 0.12 g of the product (63% yield). LCMS: m/z=549 (M+1)

1. customThe reaction mixture was partitioned between ethylacetate and water
2. washThe organic layer was washed with water, brine solution
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationthe filtrate was concentrated
6. customPurification by column chromatography on silica gel (2% MeOH in DCM)